Bona Bio has successfully applied membrane separation technology to the clarification and sterilization process of traditional Chinese medicine oral liquid, optimizing traditional processes and designing a complete set of microfiltration and ultrafiltration membrane separation systems suitable for the production of traditional Chinese medicine oral liquid. These systems have been widely used in industry and can effectively solve bacterial pollution and product turbidity, ensuring product quality while bringing considerable economic benefits to the enterprise. Combining our own professional key technologies and selecting different material separation membrane elements for different compound oral formulations, under different operating parameters, the oral liquid ensures the transfer of content indicators, while solving the problem of clarification and filtration, sealing and sterilization of oral liquid, and long-term storage, it still remains clear and transparent, with no visible foreign objects detected by the light, and good color.

The application process of membrane separation technology in traditional Chinese medicine oral liquid:

Extraction solution → Plate frame/titanium rod filtration → Single effect/double effect concentration → Alcohol sedimentation, water sedimentation → Ultrafiltration membrane filtration → Sealing → Sterilization → Finished product

Traditional Chinese Medicine Oral Liquid Membrane Separation Technology:

The relative molecular weight of active ingredients in traditional Chinese medicine is generally small, while the relative molecular weight of ineffective ingredients is large. Therefore, membrane separation ultrafiltration technology can be used to remove polymer impurities without losing the effective ingredients of the medicine. Ultrafiltration membrane technology selects membranes with different pore sizes and operating parameters based on molecular weight, structure, solution temperature, concentration, pH value, viscosity, etc. Based on the selective screening principle of membranes, it intercepts macromolecular impurities, allowing the effective components of traditional Chinese medicine to penetrate, and the ineffective components of polymers to be intercepted, thus achieving the effect of clarification, impurity removal, and long-term absence of precipitation.

Technical characteristics of ultrafiltration membrane filtration for traditional Chinese medicine oral liquid:

(1) Ultrafiltration membrane has high filtration accuracy, clear and transparent permeate, and improves product quality;

(2) Homogeneous filtration with minimal loss of active ingredients;

(3) Reduce the loss of consumables and reduce enterprise costs;

(4) Cross flow filtration can solve the problem of contamination and blockage in high concentration pharmaceutical liquid filtration;

(5) The membrane system has a high degree of self-control and is easy to operate, clean, and maintain;

(6) The equipment uses sanitary grade materials and meets GMP certification standards.