With the continuous innovation of technology, membrane separation technology and continuous moving bed technology have gradually replaced traditional plate frame filtration, fixed bed and other equipment in the process of antibiotic extraction, effectively solving the problems of poor antibiotic quality, outdated technology, and poor production environment. Membrane separation technology and continuous moving bed technology are widely used in the production of antibiotics, such as penicillin, cephalosporins, erythromycin, colistin sulfate, etc.

Membrane extraction process for antibiotics:

Traditional antibiotic extraction process: fermentation broth → filtration or centrifugation or macroporous resin adsorption, extraction → concentration → decolorization → drying → product.

The use of membrane separation technology can be simplified as follows: fermentation broth → ultrafiltration → nanofiltration (or reverse osmosis) → decolorization → drying → product.

Antibiotic extraction membrane technology:

The traditional process was improved. The Ceramic membrane ultrafiltration (membrane aperture 50nm) technology was used to separate and remove impurities from the acid adjusted colistin sulfate fermentation broth, replacing the traditional plate and frame filter pressing technology. When the concentration was three times, the yield was increased to more than 95% through intermittent water dialysis, greatly improving the product yield and product quality.

     The sugar removal and purification system utilizes a nanofiltration membrane separation technology with high separation efficiency and a molecular weight of 600 to remove sugar from the ultrafiltration filtrate. The permeate of nanofiltration only contains monosaccharides, which can be discharged into the sewage treatment pipeline. The nanofiltration process is completely a physical process, operated at room temperature, with phase change occurring, low energy consumption, stable product quality, and a yield of colistin sulfate exceeding 95%.

Membrane separation technology and continuous moving bed technology are widely used in the antibiotic industry:

1. Use Ceramic membrane and flat membrane instead of plate frame and other traditional filtration methods to clarify fermentation broth, improve filtrate quality, and reduce resin pollution and solvent consumption in the subsequent process

2. Apply ultrafiltration membrane for protein removal and decolorization to achieve high-quality

3. Using nanofiltration membranes to concentrate antibiotics, replacing or shortening evaporation concentration time; Increase crystallization yield or reduce evaporation loss

4. Replacing fixed beds with continuous moving beds to save resin usage and reduce unit consumption

5. Membrane technology for recycling various mother liquids, waste liquids, and reclaimed water for reuse

Membrane separation technology for antibiotics has the following characteristics:

1. High separation accuracy, clear and transparent filtrate, low impurity content, greatly reducing the difficulty of subsequent processing;

2. Separation at room temperature is suitable for the separation, concentration, and purification of heat sensitive substances (such as drugs, fruits, enzymes, etc.);

3. It can achieve high magnification concentration and significantly increase the product yield (5-12%) compared to traditional processes. The concentrated bacterial body can be recycled as feed;

4. Greatly reduce water usage and reduce wastewater discharge;

5. The matched ion exchange resin and macroporous adsorption resin can extend the service life by 2-3 times;

6. Asymmetric membrane pore size distribution, less prone to contamination, can maintain long-term stable filtration at high throughput;

7. The membrane components have a long lifespan, simple regeneration, low cost, stable operation process, and fully guaranteed product quality;

8. The membrane materials and auxiliary equipment materials are all pollution-free materials that comply with GMP specifications;

9. It can achieve full automatic control of the PLC upper computer, with simple operation, greatly reducing labor intensity, and easy cleaning and maintenance;

10. Supporting nanofiltration concentration to form a membrane integrated system.