Continuous ion exchange is an emerging separation technology that combines the advantages of continuous countercurrent system technology with existing adsorption, ion exchange, and chromatographic separation technologies. However, it is different from traditional systems such as fixed bed, pulse bed, and simulated moving bed. The continuous ion exchange system originated in the 1980s, when AST Company in the United States developed a new type of ion exchange system - ISEP rotary simulated moving bed system, which consists of a multi slot distribution valve and a mechanical rotary table. After passing through the distribution valve, the fluid enters different resin columns to form reverse contact flow. ISEP divides the traditional fixed bed into several small exchange columns, which are driven by a rotating disk to rotate the resin column, transforming the traditional fixed bed technology into continuous operation and greatly improving separation efficiency.

ISEP has been continuously improving in its development process, and the second generation equipment, the SepTor system, has become relatively more convenient in system operation, installation, maintenance, and other aspects. However, due to the large turntable system, complex mechanical mechanisms, and high production costs, it has not been widely applied and promoted in enterprises. With the expansion of production scale, the amount of resin used increases, and the size of resin columns and turntables continues to increase, resulting in a series of new problems such as overload and easily worn parts in the SepTor system.

Bona Bio Group has continuously innovated and boldly developed and upgraded its technology to address the shortcomings of the original system, and has developed a new generation of ion exchange systems - simulated continuous ion exchange systems. The simulated continuous ion exchange system eliminates all rotary table systems, and the resin columns are fixed and installed, greatly simplifying the mechanical structure and control scheme. The technical personnel adopted a clever idea to distribute different liquid flows into the resin column according to the requirements of the process flow through the circular groove and opening in the DCS and valve, thus achieving the fixed installation of the resin column and eliminating the rotary table system, opening a new chapter in the continuous countercurrent ion exchange and chromatographic separation technology of the rotary table. On the basis of significantly reducing resin usage, the rotary table was reduced, reducing costs, Solved the problem of liquid leakage during switching after rotating the rotary table after long-term use of traditional continuous defoliation. Simultaneously expanding the production capacity of products.

1. Due to continuous operation, the product composition and concentration remain stable after adsorption or ion exchange.

2. Due to continuous production, there is no need for repetitive equipment and no need to stop operation for regeneration. Meanwhile, the investment cost is low and maintenance is simple.

3. Compared to fixed bed systems, the resin dosage can be reduced by 50-90%. Due to the use of countercurrent regeneration method and a nearly equivalent ratio of regeneration agent, the amount of regeneration agent is significantly reduced, and the amount of washing water can be saved by 50-70%.

4. Simultaneously, substances with different characteristics can be removed or separated, thus simplifying complex processes.

5. Due to the compact nature of the equipment, it is easy to install in any location and is easily compatible with the original production process and equipment.

6. According to the needs of the production process, the rotation speed can be automatically adjusted according to the changes in the quality and flow rate of the inflow fluid. Therefore, it can ensure better economic operation.

7. According to the convenience of the production process, the flow direction of the fluid can be connected into a countercurrent or parallel flow mode.